Abstract: An ideal scaffold is the basic requirement for constructing a tissue engineering cornea. Currently, the common scaffolds includ biological materials, artificial materials and composite materials. Amnion, acellular corneal stroma and other biological materials belong to natural structures, with good histocompatibility, containing a variety of cytokines, and being non-irritating to body, but with limited sources and poor plasticity. Synthetic materials such as PGA have wide variety of sources, simple fabrication process, and controllable mechanical properties, but the metabolic process in the body is unclear. Composite material combines the advantages of bio- and organic synthetic material, but the mixing ratio of composite materials, biocompatibility and other physical and chemical characteristics need further study. Therefore, searching for a scaffold with higher biological activity, security, and transparency for tissue engineering is still the focus of the current corneal tissue engineering study.  (Int Rev Ophthalmol, 2015, 39：210-215)